Protein Details: Potassium voltage-gated channel subfamily A member 10
Protein ID
ICDB_Pro_0085
Protein Name
Potassium voltage-gated channel subfamily A member 10
Gene Name
Kcna10
Organism
Mus musculus (Mouse)
Length
511 amino acids
AlphaFoldDB
AF-B2RQA1-F1-model_v4.pdb
Function
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP
Sequence
MDVCSWKEMEVALVNFDNSDEIHEEPGYATDFDPTSSKGRPGSSPFSNWRVLISDNTNHETAFSKIPGEYVDPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKPNIPGELDKILNSMGSRMGSTESLNKTNGSCSAEKSRK
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed strongly in the inner ear and weakly in skeletal muscle. Not detected in other tissues.
DOI ID
10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/j.gep.2012.03.001; 10.1016/j.heares.2013.02.009
RefSeq
NP_001074609.1